Description

Cancer Cell Line Encyclopedia (CCLE), have provided a rigorous framework with which to study genetic variants, candidate targets, and small-molecule and biological therapeutics and to identify new marker-driven cancer dependencies.

Data Access

ChIPBase v3.0 does not provide a way to download the source expression file, you may download RNA-seq data in CCLE website.

References

[1] Nusinow D, Szpyt J, Ghandi M, Rose C, McDonald R, Kalocsay M, Jané-Valbuena J, Gelfand E, Schweppe D, Jedrychowski M, et al. Quantitative Proteomics of the Cancer Cell Line Encyclopedia. Cell. 2020;180(2):387-402.e16.
[2] Ghandi M, Huang F, Jané-Valbuena J, Kryukov G, Lo C, McDonald R, Barretina J, Gelfand E, Bielski C, Li H, et al. Next-generation characterization of the Cancer Cell Line Encyclopedia. Nature. 2019;569(7757):503-508.
[3] Li H, Ning S, Ghandi M, Kryukov G, Gopal S, Deik A, Souza A, Pierce K, Keskula P, Hernandez D, et al. The landscape of cancer cell line metabolism. Nat Med. 2019;25(5):850-860.
[4] Cancer Cell Line Encyclopedia Consortium, Genomics of Drug Sensitivity in Cancer Consortium. Pharmacogenomic agreement between two cancer cell line data sets. Nature. 2015;528(7580):84-7.
[5] Jaffe J, Wang Y, Chan HM, Zhang J, Huether R, Kryukov G, Bhang H-eun, Taylor J, Hu M, Englund N, et al. Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia. Nat Genet. 2013;45(11):1386-91.
[6] Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin A, Kim S, Wilson C, Lehár J, Kryukov G, Sonkin D, et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 2012;483(7391):603-7.
[7] Solit D, Garraway L, Pratilas C, Sawai A, Getz G, Basso A, Ye Q, Lobo J, She Y, Osman I, et al. BRAF mutation predicts sensitivity to MEK inhibition. Nature. 2006;439(7074):358-62.
[8] Garraway L, Widlund H, Rubin M, Getz G, Berger A, Ramaswamy S, Beroukhim R, Milner D, Granter S, Du J, et al. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature. 2005;436(7047):117-22.

Credits

Thanks to CCLE team for generating, processing the RNA-seq data and making them available on CCLE website.

Data Use Policy

CCLE data are available for use without restrictions. Details are described in CCLE.