Description:

Here, we presented the RBP-RNA interactions supported by the binding sites of RBPs derived from CLIP-seq data. All identified binding sites within 200bp of a RBP will be defined as a RBP-binding cluster.

Please note that 'NA' values in HepG2(shRNA/CRISPR) or K562(shRNA/CRISPR) columns mean that there were no siginificant (FDR <= 0.1) changes of gene expressions detected following RBP silcencing (knockout) or the RNA-seq data of RBP silencing (knockout) were not available.

Usage:

Select the RBP parameter to browse the RBP-mRNA interactions (selected RBP or all RBPs).
Select the target parameter to browse the RBP-mRNA interactions (selected target gene or all target genes).
Refine results with the CLIP Data parameter (the number of supported AGO-CLIP-seq experiments).
Refine results with the CLIP Region Type parameter (the type of supported RBP-binding events identified by rbsSeeker: peak or individual cross-linking site).
Refine results with the CLIP Region P-value parameter (the minimum significance of supported RBP-binding events identified by rbsSeeker).
Refine results with the CLIP-seq Type parameter (the supported CLIP-seq methodologies: e.g., HITS-CLIP, iCLIP, PAR-CLIP or eCLIP).
Explore the interaction of RBP-mRNA supported by Pan-Cancer analysis (the number of cancer types with significant co-expression patterns of the RBP-mRNA interaction).
Users can filter the results by searching in the table. The searchable columns are allowed using comparison operators like ">=", "<=", ">", "<" and "=". The ">=" is set by default.